GENETICS AND GENOMICS JOURNAL
Department: Microbiology and Immunology
University: Chang Gung University
Dr. Sen-Yung Hsieh earned his MD degree from the National Yang Ming University in 1983, and Ph.D. in Molecular Virology from the University of Pennsylvania in 1991. He completed his clinical training in internal medicine with a specialty in hepatogastroenterology in Chang Gung Memorial Hospital (CGMH), Linko, Taiwan. Currently, he is a Professor in Medicine and in Microbiology and Immunology at the Chang Gung University (CGU), and Professor in Internal Medicine and Hepato-Gastroenterology at CGMH. He was entitled to establish the Clinical Proteomics Lab at CGMH in 2004. He is now the Director of the Department of Medical Research of Linko CGMH (since September 2010 to date).T
He initially focused on the molecular virology and epidemiology of human hepatitis viruses. His team for the first time identified the zoonotic transmission of hepatitis E virus from swine to humans in 1998, which was later found in other wild and domestic animals as natural reservoirs for sporadic hepatitis E in Japan and western countries. Currently, Dr. Hsieh is interested in elucidation the molecular mechanisms involving in carcinogenesis of human hepatoma. By integration of both functional genomics and mol and cellular biology approaches, he has identified novel genes and pathways that play significant roles in the oncogenesis of human hepatoma. He published some articles in reputable journals. He has received many national and international awards.
His research interest focused on Hepatocellular carcinoma: carcinogenesis mechanisms, diagnosis, and treatments; Functional genomics for novel genes and pathways implicated in hepatocellular carcinogenesis.
Description: Via a loss-of-function approach, we have been engaged in genomewide search for genes and pathways that are implicated in the development and progression of HCC, as well as in primary and acquired resistance to anti-HCC therapies.
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