Director Unit of Plastic Reconstructive Surgery,I.R.C.C.S. – Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy
Corresponding author details:
Tommaso Fabrizio, Director
Unit of Plastic Reconstructive Surgery
I.R.C.C.S. – Referral Cancer Center of Basilicata
Rionero in Vulture (Pz),Italy
Copyright:
© 2020 Fabrizio T. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 international License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
The purpose of our study is to obtain, by electroporation, the reduction of the volume of the
neoplastic lesion or the creation of a good cleavage plan, detaching the neoplastic mass from
important vascular or nervous structures, so as to make a surgical intervention with radical
intent, otherwise not executable. This method has been used in patients suffering from
recurrence or cutaneous or subcutaneous metastasis of malignant neoplasms of different
histology, already treated with standard therapeutic procedures (surgery, chemotherapy,
radiotherapy) and currently deemed inoperable.
Electrochemotherapy; bleomycin; Malignant tumors with skin localization
85 patients with head and neck cancer were treated with this new procedure 69 patients
had squamous cell carcinoma, 16 patients with squamous cell carcinoma metastasis. The
age group was between 65 and 86 years old, the average was 75.7.
In all patients, after an average of 40 days we found a reduced tumor size, assessed with
objective and documented clinical and radiological tests, and bleeding arrest. This allowed
radical surgery to be performed, which would otherwise not be possible (Figure 1).
Figure 1: Electro-chemotherapy in Head and Neck Cancer
The results could be considered truly effective in order to emphasize the possibilities
of electrochemotherapy neoadjuvant treatment for the surgical approach to malignant
neoformations, considered otherwise inoperable in size and localization.
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