1
1st and 2nd degree Specialist in Family Medicine, Provincial Association of Family Medicine, Holguin, Cuba
2
1st degree Specialst in Family Medicine, Provincial Association of Family Medicine, Habana, Cuba
3
1st degree Specialist in Dermatology, Camaguey, Cuba
4
MBBS Bachelor on Medicine and Surgery, Nigeria
5
Pharmacist, Pakistan
Corresponding author details:
Yacquelynes Corona Hechavarria Y, Assistant Professor
MSC in comprehensive care of women
University of Medical Sciences
Holguin,Cuba
Copyright:
© 2020 Hechavarria YC, et al. This
is an open-access article distributed under the
terms of the Creative Commons Attribution
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unrestricted use, distribution, and reproduction
in any medium, provided the original author and
source are credited
Liquenscrofulosorum, also known as tuberculosis cutis lichenoides, is a rare tuberculid
that presents as lichenoid eruptions of minute papule, is an uncommon disease and easily
misdiagnosed. The lesions are usually asymptomatic, closely grouped, skin colored to
reddish-brown papules, often perifollicular. The eruption usually is associated with strongly
positive tuberculin reaction. Diagnosis of the lesions can be difficult, as they resemble many
other dermatological conditions that are often primarily considered. We report a case of
lichen scrofulosorum in an adult male with a florid medical history. He responded promptly
to antitubercular therapy with a complete clearance of the lesions after one month.
Lichen Scrofulosorum; Tuberculid; Antitubercular Therapy
This case highlights the uncommon, easily mis diagnosed but readily treatable case of
lichen scrofulosorum.
Liquen scrofulosorum., also known as tuberculosis cutis lichenoides, is a rare tuberculid
that presents as lichenoid eruptions of minute papule, is an uncommon disease and easily
misdiagnosed. The lesions are usually asymptomatic, closely grouped, skin colored to
reddish-brown papules, often perifollicular.
A 50 -year-old male presented with a history of itching skin rash for 1 month, accompanied by cough and shortness of breath more intense at night, he reports that the lesions started in the face and now is spread all over the body.
An examination revealed Vital signs: BP: 83/59 mmHg,
Pulse: 128, Spo2: 93% HB:7,8 g/dl HGT: 8,9 mmol/L
Skin: Generalized erythematous popular rash over the body from the face till the feet, with some lesions in plaques on the chest, not blister or vesicles.
Mouth: Whitish lesions in the oral mucous extended to the soft paladar.
Chest: A Skin biopsy was planned in consensus with the dermatologist (Figure 1-3).
Figure 1: Lesions on the chest
Figure 2: Plaque lesions on the neck, shoulders and scalp
Figure 3: Lesions on the L shoulder, arm and back
FBC, Sputum for GeneXpert, culture and cytology, Chest x rays, skin biopsy, CD4,V Load, Hepatitis B.
FBC CD4:9 Cryptococcal Antigen: Negative
WCC: 1,97 V Load: < 50 copies/ml
RCC: 4,00 Hepatitis B: Negative HB:10,9
Sputum: GeneXpert: Mycobacterium TB not detected
Hematocrit:0,348
Culture: Normal respiratory flora isolated
Platelet: 750 Cytology: Mixed non-specific bacterial flora
Fungal organisms detected.
The features are in keeping with Lichen Scrofulosorum.
There is not atypia or invasive malignancy seen.
Fluconazol 200 mg daily x14/7
Allergex 4mg tds
Vit C 1 g daily
Emulsifying ointment as soap
RHZE (150/75/400/275) 4 tablets daily x 2 months
RH (300/150) 2 tablets daily x 4 months.
His skin condition improved within 3 weeks of treatment, patient in the second phase of treatment and the following is his actual skin condition.
Antitubercular therapy started with conventional four firstline drugs (isoniazid, rifampin, pyrazinamide and ethambutol in
daily dose regimen) for 2 months followed by two drugs (isoniazid
and rifampin) for 4 months. His constitutional symptoms improved
within 2 weeks of starting antitubercular therapy, and skin lesions
subsided completely within 2 months. The below pictures revealed
the improvement after 1 month of treatment. (Figure 4-8).
Figure 4: Lesions on the neck
Figure 5: Lesions in the abdomen and chest
Figure 6: Lesions on the back
Figure 7: Lesions on the R arm
Figure 8: Lesions on the chest and abdomen
The tuberculids are a form of cutaneous tuberculosis caused by hypersensitivity reactions to M tuberculosis. The concept of tuberculid was introduced by Darier [1] in 1896. In contrast to ‘true’ cutaneous tuberculosis, properties of the tuberculids were explained by a hypersensitivity response to mycobacteria or their fragments released from a different site of manifest or past tuberculous infection. Key features of tuberculids include a strongly positive tuberculin skin test, evidence of concomitant manifest or past tuberculosis and prompt response to ATT. They are classified into three types: (1) Papulonecrotic tuberculid, (2) erythema induratum of Bazin and (3) LS.
Papulonecrotictuberculid and LS represent true hypersensitivity reactions rather than the result of a local cutaneous tuberculosis infection. LS is a rare tuberculid, initially described by Hebra[2] in 1860. LS is usually seen in children and young adults suffering from systemic tuberculosis, either pulmonary or extrapulmonary, and very rarely after BCG vaccination [3]. Clinically, LS is characterised by tiny, skin coloured, perifollicular papules in groups having a smooth surface but occasionally spiny projections with fine scales may be seen. The lesions reveal non-caseating, epithelioid cell granulomas in upper dermis and around dermal appendages. Tubercle bacilli are almost never seen in the histology specimen, neither can they be cultured. However, rarely, antigen of M tuberculosis has been demonstrated in papulonecrotic tuberculid, another type of more frequently seen tuberculid [4]. Diagnosis of LS mainly lies on histopathology, tuberculin skin testing and evidence of systemic tuberculosis in the body. Treatment of LS is the same as that for systemic tuberculosis.
In a study by Varshneyet al.[5] the overall incidence of
cutaneous tuberculosis was 0.7% (131 of 18 720 outpatients). The
most common variants seen were scrofuloderma (36.5%), lupus
vulgaris (31%), tuberculosis verruca cutis (12.9%), LS (11.4%),
papulonecrotic tuberculids (3.8%), erythema nodosum (2.2%) and
erythema induratum of Bazin (1.5%). Cutaneous tuberculosis may
also be a direct manifestation of underlying tuberculosis as seen in
the case reported by Al Zayyaniet al. [6] in which chronic tuberculous
epididymo-orchitis presented as scrotal ulcers. Among the three
tuberculids, the incidence of LS was found to be lowest (2%) in a
large study conducted in Hong Kong [7]. Singhalet al. [8-12] studied
39 cases of LS, of which 72% had an underlying focus of tuberculosis
while 28% had no identifiable focus of tuberculosis.
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